228- Teoman Onat, Altan Onat, Günay Can
Negative T-wave in Chest Lead V1 : Relation to Sex and Future Cardiovascular Risk Factors Türk Kardiyoloji Dern.Arş. 2008, 36:513-518

Background: The significance of negative T-waves in lead V1 has not been clarified.

Methods: This was studied in a prospective manner in 508 middle-aged and elderly adults of the longitudinal Turkish Adult Risk Factor study in which data on prevalence of coronary heart disease and its risk factors were available for comparative assessment of T-wave groups. Criteria for exclusion of recognized situations with an inverse T-wave were described.

Results: The proportion of negative T-waves in V1, being 38.3% in females, was significantly higher than that of 7.2% in males. The associations of a variety of cardiovascular risk factors and cardiometabolic conditions were similar with respect to the direction of the T-wave pattern among men. In women presenting negative T-waves, among other risk factors, only systolic blood pressure (p=0.002) and HDL-cholesterol (p=0.034) were significantly lower. No convincing explanation could be offered for this statistically highly significant sex difference in relation to negative T-waves in lead V1.

Conclusion: Negative T waves in lead V1 occurring far more commonly in women than in men are not associated with adverse cardiometabolic risk